Sequence 1 (ABL1 , BLK , FGR , HCK ( Homo sapiens ) )

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Sequence ABL1 , BLK , FGR , HCK ( Homo sapiens )
Target ABL1 , BLK , FGR , HCK ( Homo sapiens )
Description ENSG00000097007 9:130713946-130887675:1 ABL proto-oncogene 1,non-receptor tyrosine kinase ; ENSG00000136573 8:11494001-11564604:1 BLK proto-oncogene, Src family tyrosine kinase ; ENSG00000000938 1:27612064-27635277:-1 FGR proto-oncogene, Src family tyrosine kinase ; ENSG00000101336 20:32052188-32101856:1 HCK proto-oncogene, Src family tyrosine kinase
Design gapmer
Chemistry +T*+T*+G*A*T*G*G*G*G*A*A*C*T*+T*+G*+G
Sequence TTGATGGGGAACTTGG
Application gene silencing , multitargeting
Name ABL1 , BLK , FGR , HCK ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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