Sequence 1 (ACVR2B , ARAF , CHEK1 , FGR ( Homo sapiens ) )

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Sequence ACVR2B , ARAF , CHEK1 , FGR ( Homo sapiens )
Target ACVR2B , ARAF , CHEK1 , FGR ( Homo sapiens )
Description ENSG00000114739 3:38453851-38493142:1 Activin A receptor, type IIB ; ENSG00000078061 X:47561100-47571920:1 A-Raf proto-oncogene, serine/threonine kinase ; ENSG00000149554 11:125625136-125676255:1 Checkpoint kinase 1 ; ENSG00000000938 1:27612064-27635277:-1 FGR proto-oncogene, Src family tyrosine kinase
Design gapmer
Chemistry +G*+C*+C*A*A*G*C*C*A*A*A*+G*+T*+C
Sequence GCCAAGCCAAAGTC
Application gene silencing, multitargeting
Name ACVR2B , ARAF , CHEK1 , FGR ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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