Sequence 1 (BIRC5 , HK2 , USP34 ( Homo sapiens ) )

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Sequence BIRC5 , HK2 , USP34 ( Homo sapiens )
Target BIRC5 , HK2 , USP34 ( Homo sapiens )
Description ENSG00000089685 17:78214186-78225636:1 Baculoviral IAP repeat containing 5 ; ENSG00000159399 2:74833981-74893359:1 Hexokinase 2 ; ENSG00000115464 2:61187463-61470769:-1 Ubiquitin specific peptidase 34
Design gapmer
Chemistry +T*+T*+G*G*T*T*T*C*C*T*T*+T*+G*+C
Sequence TTGGTTTCCTTTGC
Application Gene silencing , multitargeting
Name BIRC5 , HK2 , USP34 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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