Sequence 1 (CAMK2A , CDK4 , CDK16 , FIP1L1 , HCK , IRAK1 , PDGFRA ( Homo sapiens ) )

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Sequence CAMK2A , CDK4 , CDK16 , FIP1L1 , HCK , IRAK1 , PDGFRA ( Homo sapiens )
Target CAMK2A , CDK4 , CDK16 , FIP1L1 , HCK , IRAK1 , PDGFRA ( Homo sapiens )
Description ENSG00000070808 5:150219491-150290291:-1 Calcium/calmodulin-dependent protein kinase II alpha ; ENSG00000135446 12:57747727-57756013:-1 Cyclin-dependent kinase 4 ; ENSG00000102225 X:47217860-47229997:1 Cyclin-dependent kinase 16 ; ENSG00000145216 4:53377643-53460861:1 Factor interacting with PAPOLA and CPSF1 ; ENSG00000101336 20:32052188-32101856:1 HCK proto-oncogene, Src family tyrosine kinase ; ENSG00000184216 X:154010500-154019980:-1 Interleukin-1 receptor-associated kinase 1 ; ENSG00000134853 4:54229097-54298247:1 Platelet-derived growth factor receptor, alpha polypeptide
Design Gapmer
Chemistry +G*+G*+C*C*A*G*G*C*C*A*A*A*+G*+T*+C
Sequence GGCCAGGCCAAAGTC
Application gene silencing , multitargeting
Name CAMK2A , CDK4 , CDK16 , FIP1L1 , HCK , IRAK1 , PDGFRA ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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