Sequence 1 (CARD9 , IL7R , RPL5 ( Homo sapiens ) )

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Sequence CARD9 , IL7R , RPL5 ( Homo sapiens )
Target CARD9 , IL7R , RPL5 ( Homo sapiens )
Description ENSG00000187796 9:136361903-136373681:-1 Caspase recruitment domain family, member 9 ; ENSG00000168685 5:35852695-35879603:1 Interleukin 7 receptor ; ENSG00000122406 1:92832025-92841924:1 Ribosomal protein L5
Design gapmer
Chemistry +C*+C*+A*A*C*C*T*T*C*A*+C*+A*+C
Sequence CCAACCTTCACAC
Application Gene silencing , multitargeting
Name CARD9 , IL7R , RPL5 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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