Sequence 1 (E2F1 , FGFR1 , FGFR3 , FGFR4 , HSPA12A ( Homo sapiens ) )

Sequence E2F1 , FGFR1 , FGFR3 , FGFR4 , HSPA12A ( Homo sapiens )
Target	E2F1 , FGFR1 , FGFR3 , FGFR4 , HSPA12A ( Homo sapiens )
Description	ENSG00000101412 20:33675683-33686404:-1 E2F transcription factor 1 ; ENSG00000077782 8:38411138-38468834:-1 Fibroblast growth factor receptor 1 ; ENSG00000068078 4:1793307-1808872:1 Fibroblast growth factor receptor 3 ; ENSG00000160867 5:177086886-177098144:1 Fibroblast growth factor receptor 4 ; ENSG00000165868 10:116671192-116742574:-1 Heat shock 70kDa protein 12A
Design	Gapmer
Chemistry	+A*+G*+C*C*A*C*T*G*G*A*T*+G*+T*+G
Sequence	AGCCACTGGATGTG
Application	Gene silencing , multitargeting
Name	E2F1 , FGFR1 , FGFR3 , FGFR4 , HSPA12A ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530.

Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background