Sequence 1 (EBAG9 , MCL1 , PTGS2 , TMED7-TICAM2 ( Homo sapiens ) )

Sequence EBAG9 , MCL1 , PTGS2 , TMED7-TICAM2 ( Homo sapiens )
Target	EBAG9 , MCL1 , PTGS2 , TMED7-TICAM2 ( Homo sapiens )
Description	ENSG00000147654 8:109539711-109565996:1 Estrogen receptor binding site associated, antigen, 9 ; ENSG00000143384 1:150574551-150579738:-1 Myeloid cell leukemia 1 ; ENSG00000073756 1:186671791-186680427:-1 Prostaglandin-endoperoxide synthase 2 ; ENSG00000251201 5:115578642-115626161:-1 TMED7-TICAM2 readthrough
Design	gapmer
Chemistry	+T*+G*+T*G*A*T*A*C*T*T*T*+C*+T*+G
Sequence	TGTGATACTTTCTG
Application	Gene silencing , multitargeting
Name	EBAG9 , MCL1 , PTGS2 , TMED7-TICAM2 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530.

Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background