Sequence 1 (FGFR1 , FGFR4 , TERT ( Homo sapiens ) )

Sequence FGFR1 , FGFR4 , TERT ( Homo sapiens )
Target	FGFR1 , FGFR4 , TERT ( Homo sapiens )
Description	ENSG00000077782 8:38411138-38468834:-1 Fibroblast growth factor receptor 1 ; ENSG00000160867 5:177086886-177098144:1 Fibroblast growth factor receptor 4 ; ENSG00000164362 5:1253147-1295069:-1 Telomerase reverse transcriptase
Design	gapmer
Chemistry	+C*+A*+C*C*T*G*G*T*A*G*G*C*+G*+C*+A
Sequence	CACCTGGTAGGCGCA
Application	Gene silencing , multitargeting
Name	FGFR1 , FGFR4 , TERT ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530.

Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background