Sequence 1 (IL6R , TLR9 ( Homo sapiens ))

Sequence IL6R , TLR9 ( Homo sapiens )
Target	IL6R , TLR9 ( Homo sapiens )
Description	ENSG00000160712 1:154405193-154469450:1 Interleukin 6 receptor ; ENSG00000239732 3:52221080-52226163:-1 Toll-like receptor 9
Design	Gapmer
Chemistry	+C*+C*+G*T*G*G*G*T*C*C*C*T*G*+G*+C*+A
Sequence	CCGTGGGTCCCTGGCA
Application	Gene silencing , multitargeting
Name	IL6R , TLR9 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530.

Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background