Sequence 1 (KRT17 , NLRP1 ( Homo sapiens ) )

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Sequence KRT17 , NLRP1 ( Homo sapiens )
Target KRT17 , NLRP1 ( Homo sapiens )
Description ENSG00000128422 17:41619437-41624842:-1 Keratin 17, type I ; ENSG00000091592 17:5499427-5619424:-1 NLR family, pyrin domain containing 1
Design gapmer
Chemistry +T*+C*+T*C*C*T*T*C*C*T*C*T*G*+C*+T*+T
Sequence TCTCCTTCCTCTGCTT
Application Gene silencing , multitargeting
Name KRT17 , NLRP1 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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