Sequence 187 (Mu3A)
| Sequence Mu3A | |
|---|---|
| Target | AP3M1 ( Homo sapiens ) |
| Description | Adaptor-related protein complex 3, mu 1 subunit
Ensembl: ENSG00000185009 UniGene: Hs.500104 EntrezGene: 26985 Ensembl Chr10: 75550022 - 75580832 Strand: -1 GO terms: 0005515 0005764 0005794 0006461 0006622 0006810 0006886 0008565 0016192 0030117 0030131 |
| Design | siRNA |
| Chemistry | RNA |
| Sequence | siRNA sense (19b) GGAGAACAGTTCTTGCGGC / siRNA antisense (19b) GCCGCAAGAACTGTTCTCC |
| Application | gene silencing |
| Name | Mu3A |
References
Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments.McCormick PJ, Martina JA, Bonifacino JS.Proc Natl Acad Sci U S A. 2005 May 31;102(22) :7910-5. Epub 2005 May 23.
Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478
Comments
Background
Description. AP3M1 is a subunit of the AP3 complex that functions in cargo-selective transport of proteins from the Golgi to the lysosome. Other subunits of this complex are beta-3 (see AP3B1; 603401), AP3D1 (607246), and sigma-3 (see AP3S1; 601507) (Odorizzi et al., 1998). Gene Function. Dell'Angelica et al. (1999) found that the mu-3A subunit of AP3 interacts with tyrosine-based lysosome targeting signals in cargo proteins and thereby assists in their targeting from the Golgi to lysosomes.
