Sequence 1 (ATR , MKI67 , PKN3 ( Homo sapiens ) )

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Sequence ATR , MKI67 , PKN3 ( Homo sapiens )
Target ATR , MKI67 , PKN3 ( Homo sapiens )
Description ENSG00000175054 3:142449235-142578826:-1 ATR serine/threonine kinase ; ENSG00000148773 10:128096659-128126385:-1 Marker of proliferation Ki-67 ; ENSG00000160447 9:128702523-128720918:1 Protein kinase N3
Design gapmer
Chemistry +A*+G*+G*T*C*C*A*G*T*T*T*+C*+T*+G
Application Gene silencing , multitargeting
Name ATR , MKI67 , PKN3 ( Homo sapiens )


Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530.

Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478


Not experimentally validated


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