Sequence 1 (BCL2 , HIF2 , PSMA6 ( Homo sapiens ))

Sequence BCL2 , HIF2 , PSMA6 ( Homo sapiens )
Target	BCL2 , HIF2 , PSMA6 ( Homo sapiens )
Description	ENSG00000171791 18:63123346-63320128:-1 B-cell CLL/lymphoma 2 ; ENSG00000116016 2:46293667-46386703:1 Endothelial PAS domain protein 1 ; ENSG00000100902 14:35278633-35317493:1 Proteasome (prosome, macropain) subunit, alpha type, 6
Design	Gapmer
Chemistry	+T*+G*+T*C*A*G*C*T*G*T*C*+A*+T*+T
Sequence	TGTCAGCTGTCATT
Application	Gene silencing , multitargeting
Name	BCL2 , HIF2 , PSMA6 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530.

Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background