Sequence 1 (C-KIT , C-MET , CSF1R , FGFR1 , FGFR3 , FGFR4 , FIP1L1 , MST1R , PDGFRA ( Homo sapiens ) )

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Sequence C-KIT , C-MET , CSF1R , FGFR1 , FGFR3 , FGFR4 , FIP1L1 , MST1R , PDGFRA ( Homo sapiens )
Target C-KIT , C-MET , CSF1R , FGFR1 , FGFR3 , FGFR4 , FIP1L1 , MST1R , PDGFRA ( Homo sapiens )
Description ENSG00000157404 4:54657918-54740715:1 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog ; ENSG00000105976 7:116672390-116798386:1 MET proto-oncogene, receptor tyrosine kinase ; ENSG00000182578 5:150053291-150113372:-1 Colony stimulating factor 1 receptor ; ENSG00000077782 8:38411138-38468834:-1 Fibroblast growth factor receptor 1 ; ENSG00000068078 4:1793307-1808872:1 Fibroblast growth factor receptor 3 ; ENSG00000160867 5:177086886-177098144:1 Fibroblast growth factor receptor 4 ; ENSG00000145216 4:53377643-53460861:1 Factor interacting with PAPOLA and CPSF1 ; ENSG00000164078 3:49887002-49903873:-1 Macrophage stimulating 1 receptor ; ENSG00000134853 4:54229097-54298247:1 Platelet-derived growth factor receptor, alpha polypeptide
Design Gapmer
Chemistry +G*+C*+C*A*T*C*C*A*C*T*T*+C*+A*+C
Sequence GCCATCCACTTCAC
Application Gene silencing , multitargeting
Name C-KIT , C-MET , CSF1R , FGFR1 , FGFR3 , FGFR4 , FIP1L1 , MST1R , PDGFRA ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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