Sequence 1 (CCNE2 , FGFR1 , FGFR3 , FGFR4 ( Homo sapiens ) )

Sequence CCNE2 , FGFR1 , FGFR3 , FGFR4 ( Homo sapiens )
Target	CCNE2 , FGFR1 , FGFR3 , FGFR4 ( Homo sapiens )
Description	ENSG00000175305 8:94879770-94896678:-1 Cyclin E2 ; ENSG00000077782 8:38411138-38468834:-1 Fibroblast growth factor receptor 1 ; ENSG00000068078 4:1793307-1808872:1 Fibroblast growth factor receptor 3 ; ENSG00000160867 5:177086886-177098144:1 Fibroblast growth factor receptor 4
Design	Gapmer
Chemistry	+A*+C*+C*A*G*C*T*G*C*T*T*G*+A*+A*+G
Sequence	ACCAGCTGCTTGAAG
Application	gene silencing , multitargeting
Name	CCNE2 , FGFR1 , FGFR3 , FGFR4 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530.

Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background