Sequence 1 (DOCK7 , TGFB2 , USP14 ( Homo sapiens ) )

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Sequence DOCK7 , TGFB2 , USP14 ( Homo sapiens )
Target DOCK7 , TGFB2 , USP14 ( Homo sapiens )
Description ENSG00000116641 1:62454728-62688368:-1 Dedicator of cytokinesis 7 ; ENSG00000092969 1:218346235-218444619:1 Transforming growth factor, beta 2 ; ENSG00000101557 18:158383-214629:1 Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Design gapmer
Chemistry +G*+T*+T*A*C*A*A*G*C*A*T*+C*+A*+T
Sequence GTTACAAGCATCAT
Application Gene silencing , multitargeting
Name DOCK7 , TGFB2 , USP14 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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