Sequence 1 (EGFR , FGFR1 , HER2 ( Homo sapiens ) )

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Sequence EGFR , FGFR1 , HER2 ( Homo sapiens )
Target EGFR , FGFR1 , HER2 ( Homo sapiens )
Description ENSG00000146648 7:55019021-55256620:1 Epidermal growth factor receptor ; ENSG00000077782 8:38411138-38468834:-1 Fibroblast growth factor receptor 1 ; ENSG00000141736 17:39687914-39730426:1 Erb-b2 receptor tyrosine kinase 2
Design Gapmer
Chemistry +A*+C*+A*T*C*A*C*T*C*T*G*G*T*G*+G*+G*+T
Sequence ACATCACTCTGGTGGGT
Application Gene silencing , multitargeting
Name EGFR , FGFR1 , HER2 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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