Sequence 1 (FGFR1 , FGFR3 , GRB7 ( Homo sapiens ) )

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Sequence FGFR1 , FGFR3 , GRB7 ( Homo sapiens )
Target FGFR1 , FGFR3 , GRB7 ( Homo sapiens )
Description ENSG00000077782 8:38411138-38468834:-1 Fibroblast growth factor receptor 1 ; ENSG00000068078 4:1793307-1808872:1 Fibroblast growth factor receptor 3 ; ENSG00000141738 17:39737927-39747291:1 Growth factor receptor-bound protein 7
Design gapmer
Chemistry +T*+C*+A*C*T*G*T*A*C*A*C*+C*+T*+T
Sequence TCACTGTACACCTT
Application Gene silencing , multitargeting
Name FGFR1 , FGFR3 , GRB7 ( Homo sapiens )

References

Identification of sequences common to more than one therapeutic target to treat complex diseases: simulating the high variance in sequence interactivity evolved to modulate robust phenotypes. Varela MA. BMC Genomics. 2015 Jul 18;16(1):530. Intrathecal Injections in Children With Spinal Muscular Atrophy: Nusinersen Clinical Trial Experience. Hache M, Swoboda KJ, Sethna N, Farrow-Gillespie A, Khandji A, Xia S, Bishop KM. J Child Neurol. 2016 Jun;31(7):899-906. PubMed:26823478

Comments

Not experimentally validated

Background

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